In the ethnicity-based subgroup analysis, XRCC3 rs861539 was associated with a reduced risk of ovarian cancer in Caucasian populations based on the heterozygote model (GA vs. GG: OR = 0.88, 95%CI = 0.81-0.96, P = 0.004) and dominant model (GG vs. GA+AA: OR = 0.88, 95%CI = 0.81-0.96, P = 0.004). The gene discussed is XRCC3; the disease is ovarian cancer.