Results showed that Chalcone 9X treatment repressed protein levels of Vimentin and N-cadherin and promoted E-cadherin expression with dose dependency in U87 and T98G cells after 48 h (Figures 3(i)–3(k)) (p < 0.05), which suggested that Chalcone 9X repressed cell migration in glioma cells. Here, VIM is linked to central nervous system cancer.