C5AR1 and Alzheimer disease: Additionally, since only female mice were used for the present study, possible microglial sex-specific changes in response to PMX205 should be assessed, although genetic ablation of C5aR1 in another mouse model of amyloidosis (Arctic) did not show sex-related effects in behavior, gliosis or gene expression in either the AD characteristics or the effect of a deletion of C5aR1 [17, 21].