Since we also reported no significant changes in the halo of microglial cells around amyloid plaques in response to C5aR1 antagonist, we could presume that a major beneficial effect in preventing the appearance of dystrophic neurites in response to PMX205 is mainly due to its impact (decrease) in the amount of amyloid pathology in the Tg2576 mouse model of AD. The gene discussed is C5AR1; the disease is amyloidosis.