The soft tissue neoplasms showed upregulation of RTKs related to fibroblast growth or ECM interaction and remodeling, such as FGFR1/2, AXL, EPHB3 and DDR2. As noted, the F9 MB-WNT showed a robust RTK program (Figs. 4B, 5G), sharing with the MB-SHH cluster similar NTRK1 and INSRR overexpression, and much higher EPH RTK overexpression, especially of EPHA3/7. Here, DDR2 is linked to soft tissue neoplasm.