Interestingly, this FAP-related soft tissue neoplasm closely clustered with the high-grade sarcoma from the LFS patient arising also post radiotherapy, and shared upregulation of common morphogenetic pathways, such as Hippo and TGFβ, and a common RTK program involved in fibroblastic differentiation (Fig. 6). Here, TGFB1 is linked to soft tissue neoplasm.