TP53 and osteosarcoma: Correlation between the TP53 mutation site and the histologic type of sarcoma has been shown, and although the R282 missense mutation, as in M6, correlates best with spontaneous occurrence of liposarcomas and osteosarcomas in LFS carriers [51], the M6 high-grade sarcoma does not correspond to either of these types and matches better the post-radiotherapy sarcoma types [50].