The association between the expression of four CXCR members (CXCR3 to CXCR6) and the favorable outcome of HNSCC patients was found, so as the association of two clinical features (age and stage) with poor outcome (hazard ratio [HR] for CXCR3: 0.649; HR for CXCR4: 0.529; HR for CXCR5: 0.623; HR for CXCR6: 0.650; HR for age: 1.024; and HR for stage: 1.448) (Table 2). The gene discussed is CXCR4; the disease is head and neck squamous cell carcinoma.