Our analysis data suggested the predictive potential of CXCR as four CXCR members (CXCR3, CXCR4, CXCR5, and CXCR6) were significantly related to better clinical outcomes in HNSCC, as reported in acute myeloid leukemia [32]. Here, CXCR4 is linked to head and neck squamous cell carcinoma.