Interestingly, in PD/GBA subjects there was an upregulation of the alpha-synuclein gene (SNCA) and related genes (i.e. POLR2D and NFATC3) compared to PD (FDR < 0.15) (Fig. 2c-d, Supplementary Fig. 5b) [60]. This evidence concerns the gene SNCA and Parkinson disease.