Consistent with previous analysis, pathway enrichment analysis of the genetic outliers of subjects in the PD/GBA group confirmed a significant enrichment of pathways related to neuroinflammation (including ICAM1, NFATC1, IRAK4), membrane bounded organelle (such as VPS41), ERK/MAPK signaling, and autophagy (such as DOCK1 - involved in cytoskeletal rearrangement for phagocytosis of apoptotic cells and mobility of the cells) (Fig. 3a-b). Here, IRAK4 is linked to Parkinson disease.