Interestingly, significant DEG included targets implicated in monogenic forms of PD (such as ATP13A2 and LRRK2), Tau-related pathways, senescence (FUCA2 and HEXB), NOTCH1-related genes (a highly conserved transmembrane domain protein that is involved in different cellular processes such as cell proliferation, differentiation, apoptotic processes, and modulation of the secretome dynamics in cells), autophagy (such as RPTOR), the endolysosomal and mitochondrial pathways, as well as genes associated with PD-GWAS loci (Fig. 2a, Supplementary Fig. 4a-b). The gene discussed is NOTCH1; the disease is Parkinson disease.