Clinical studies confirm the importance of inhibiting the CD47/SIRPα interaction in various hematological malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) [41], and relapsed/refractory non-Hodgkin’s lymphoma (R/R-NHL) [42]. The gene discussed is SIRPA; the disease is non-Hodgkin lymphoma.