MTOR and renal fibrosis: It was found that mitochondrial dysfunction was significantly improved in renal interstitial cells of UUO rats after curcumin treatment, which in turn inhibited the activation of NLRP3 inflammasome and the expression of PI3K/AKT/mTOR signaling pathway, alleviating the progression of renal fibrosis by reducing the inflammatory response and regulating autophagy [42].