Dual antiplatelet therapy with aspirin and a platelet P2Y12 receptor antagonist (P2Y12 inhibitor) is the treatment of choice for the prevention of atherothrombotic events in patients with acute coronary syndromes (ACS) [6].Clopidogrel, prasugrel, and ticagrelor are the most commonly used oral platelet P2Y12 inhibitors. The gene discussed is P2RY12; the disease is acute coronary syndrome.