Previous studies have shown that the NF-κB, MAPK, Akt (also known as protein kinase B) and interferon regulatory factor pathways, which are involved in abnormal B cell proliferation and excessive antibody production, contribute to the pathogenesis of MG and that TRAF6 is the upstream intersection of these pathways [16–20]. The gene discussed is NFKB1; the disease is myasthenia gravis.