GPT and chronic hepatitis B virus infection: The natural history of chronic HBV infection is variable, but it is generally divided into the following five stages based on the hepatitis B e-antigen (HBeAg) status, serum HBV DNA levels, alanine aminotransferase (ALT) levels, and liver disease severity stage: HBeAg-positive chronic HBV infection; HBeAg-positive chronic hepatitis B (CHB); HBeAg-negative chronic HBV infection; HBeAg-negative CHB; and hepatitis B surface antigen (HBsAg)-negative phase [2].