Ferroptosis is an iron‐dependent form of nonapoptotic cell death that is characterized by the accumulation of cytotoxic lipid reactive oxygen species (ROS) and results in lipid membrane damage and perforation.[11, 12] Activation of ferroptosis has been reported to contribute to the efficacy of cancer treatments, such as immune checkpoint blockade,[14] radiotherapy[15] and chemotherapy.[13] The classic cellular defense mechanism against ferroptosis is achieved by the glutathione peroxidase 4 (GPX4)‐xCT signaling axis. The gene discussed is SLC7A11; the disease is cancer.