LACC1 and juvenile idiopathic arthritis: Frame-shift mutations and single-nucleotide polymorphisms K38E, I254 and C284R in LACC1 identified in genome-wide association studies (GWAS) are correlated with early-onset Crohn’s disease (CD), ankylosing spondylitis, systemic juvenile idiopathic arthritis (JIA), and a high-risk state for leprosy (Mycobacterium leprae infections)12-17.