Recently, human LACC1 (hLACC1) was shown to interact with a family of autophagy-associated proteins, including autophagy inducers RACK1 and AMPK, and Lacc1 deficiency reduced autophagic flux in primary human macrophages, defining a novel form of genetically inherited JIA associated with impaired autophagy in macrophages11. The gene discussed is LACC1; the disease is juvenile idiopathic arthritis.