Mouse pancreas cancer models driven by conditional activation of an oncogenic KrasG12D allele and a single conditional inactivating allele of Trp53 (hereafter, the KPC model) result in pathophysiologically accurate PDAC that develops with near invariable loss of the remaining wild-type (WT) Trp53 allele (hereafter p53)28–30. The gene discussed is TP53; the disease is pancreatic neoplasm.