DNMT3A and aplastic anemia: In comparison, 5/14 (36%) of astronauts had at least one DNMT3A SNV, which were predominantly missense mutations in the methyltransferase domain, thus likely impacting enzyme function, or nonsense mutations (Arg771Ter, Trp305Ter) that had been identified in patients with aplastic anemia and angioimmunoblastic T Cell lymphoma22,23 (Fig. 3b).