Furthermore, gene expression of glycolytic enzymes, lactate, and glutamine metabolism (G6PDH, PKLR, PFKL, LDHA, LDHB, GLS1, GLS2, and GLUL), were upregulated in primary mouse (hACE2) and human hepatocytes upon infection compared to controls (Supplementary Fig. 4a, b). This evidence concerns the gene H6PD and infection.