KLK3 and Familial prostate cancer: The most recent systematic review of the diagnostic accuracy of PSA for prostate cancer in patients with LUTS found that a PSA threshold of 4 ng/mL had a sensitivity of 0.93 (95% CI 0.88, 0.96) and specificity of 0.20 (95% CI 0.12, 0.33), and the area under the curve (AUC) was 0.72 (95% CI 0.68, 0.76) [12].