We also identified a splice acceptor variant rs201988637 in the same gene, which is also associated with protection against coronary atherosclerosis and other representations of major CHD, indicating that rs534125149 has very similar effect on CHD as a splice acceptor variant in MFGE8. Associations of both of these two variants in MFGE8 were specific to CHD, and they did not significantly (p < 1.75 × 10−5) increase risk for any other disease, highlighting MFGE8 as a potential drug target candidate. The gene discussed is MFGE8; the disease is coronary atherosclerosis.