In addition to inframe insertion rs53412514, we identified a splice acceptor variant (rs201988637) in MFGE8 to be associated with coronary atherosclerosis (OR = 0.72 [0.63–0.83], p = 7.94 × 10−06) and multiple disease endpoints representing major CHD. This evidence concerns the gene MFGE8 and coronary atherosclerosis.