PCSK9 and coronary artery disorder: Previously, the protective effect of loss-of-function variants have been reported for example for PCSK95 and APOC36, and in phase I, II and III trials, inhibition of PCSK9 have led to significantly decreased LDL-C levels, and in short-term trials, PCSK9 inhibitors have been well-tolerated and have had a low incidence of adverse effects24 Based on the phenome-wide association profile for the splice acceptor variant rs201988637, we hypothesize that inhibiting MFGE8 could lower the CHD risk, if the variant can be proved to be loss-of-function in MFGE8.