LGR5 and breast cancer: As presented in Fig. 6a,b, Znhit1 gene expression was statistically significantly negatively correlated with tissue and serum β-catenin (r =  − 0.348, P = 0.04 and r =  − 0.352, P = 0.038; respectively), while it was insignificantly negatively correlated with ALDH1A1 and LGR5 levels in tissue and serum of BC patients.