Specifically, RET variants frequencies were the highest in uterine corpus endometrial carcinoma (UCEC, 10.4%), skin cutaneous melanoma (SKCM, 8.93%), thyroid carcinoma (THCA, 7.40%), colon and rectal adenocarcinomas (COADREAD, 5.05%), stomach adenocarcinoma (STAD, 4.09%), lung adenocarcinoma (LUAD, 3.89%), and lung squamous cell carcinoma (LUSC, 3.70%) (Fig. 1A). The gene discussed is RET; the disease is squamous cell lung carcinoma.