Results showed that the combination of STING methylation and tumor depth/lymph node metastasis/stage showed an increased prognostic accuracy (AUC = 0.683) for OS of LUAD patients than either tumor depth/lymph node metastasis/stage alone (AUC = 0.669, P = 0.321) though not statistically significant, or STING methylation alone (AUC = 0.574, P < 0.001) (Supplementary Fig. 7a) for OS of LUAD patients. This evidence concerns the gene STING1 and metastatic malignant neoplasm in the lymph nodes.