Similarly, as shown in Supplementary Fig. 7b, combining STING methylation with tumor depth/lymph node metastasis/stage resulted in an increased AUC for predicting DFS of LUAD patients than the latter alone (P = 0.277) though not statistically significant, or STING methylation alone (P = 0.001). This evidence concerns the gene STING1 and metastatic malignant neoplasm in the lymph nodes.