Furthermore, using cyclic diadenyl monophosphate (CDA) to activate STING in the LLC mouse model not only elicits potent antitumor responses but also stimulates a rapid increase of immunoregulatory pathways involving PD-1, IDO, and COX2 in the tumor microenvironment, which then attenuates antitumor responses. The gene discussed is IDO1; the disease is neoplasm.