Among the unique DMGs, we found several genes linked to neurodevelopmental disorder and ASD, including XK related 6 (XKR6) (Fig. 4a), zinc finger protein 107 (ZNF107) (Fig. 4b), and myeloma-overexpressed gene 2 protein (MYEOV2) (Fig. 4c) in the ASD with 16.p11.2 del. The gene discussed is COPS9; the disease is neurodevelopmental disorder.