We demonstrated that the hs-cTnT (adjusted HR 2.64 [1.02–6.78]), but not hs-TnI (adjusted HR 0.95 [0.31–2.85]), remained significantly associated with an increased risk of all-cause mortality after adjusting for age, atrial fibrillation, serum albumin, hemoglobin, the use of ACEi/ARB and the use of oral anticoagulant. This evidence concerns the gene TNNT2 and atrial fibrillation.