Several studies have shown that NDUFA4 encodes a subunit of the electron transport chain complex belonging to the respiratory chain of mitochondria to produce ATP, regulates oxidative phosphorylation pathway-related proteins such as COX6C, COX5B and NDUFA8 in GC cells [10], and promotes glucose uptake, lactate production and major enzymes involved in glycolysis such as PDK1, PFK1, PKM2 in colorectal cancer cells [11]. This evidence concerns the gene PKM and colorectal cancer.