PPP1CC and Familial prostate cancer: For example, downregulation of PPP1CC/PP1γ, the γ-subunit of the serine/threonine-protein phosphatase PP1 that plays an essential role in cell division and protein turnover via dephosphorylation [20], and upregulation of ADI1 (1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase), a protein involved in L-methionine synthesis previously shown to act as tumor suppressor in prostate cancer [21] were observed in JHOS2 shPTK7 cells.