Pre-challenge VirG-specific ADCP and ADCD tracked inversely with symptoms of shigellosis such as number of dysenteric stools (r = −0.2 for both, p > 0.05), and VirG-specific ADCP and ADCD before challenge were robustly negatively correlated with disease severity (Figure S5), confirming the relevance of ADCP and ADCD as correlates of immunity, as similar functions were observed for IpaB (Figure 3A). This evidence concerns the gene VIPR1 and shigellosis.