We also noted that all ROIs in IPF showed a generalized increase in the Hallmark glycolysis gene set (Figure S3I), and that this effect was greatest in fibroblastic foci that contained the largest proportion of myofibroblasts, cells that are known to switch to aerobic glycolysis in response to TGF-β (Xie et al., 2015). Here, TGFB1 is linked to idiopathic pulmonary fibrosis.