Tenascin C (TNC), a gene encoding an ECM glycoprotein that is increased in response to tissue injury, was upregulated in fibroblastic foci, but not within the alveolar septae ROIs, (Figure 4B) as well as CRABP2, a retinol-binding protein whose expression has recently been associated with IPF disease progression (Figure 4C) (Ghandikota et al., 2022). This evidence concerns the gene CRABP2 and idiopathic pulmonary fibrosis.