To validate the function of CDH2 in vivo, we explored its role in leukemia initiation and propagation in our PDX model.59, 60, 61 We transplanted luciferase-tagged leukemia blasts from a clinical sample of very-high-risk ALL (L707; Key resources table) directly into the BM of immunodeficient mice. The gene discussed is CDH2; the disease is leukemia.