Roles for DAB1 and RELN have previously been suggested in AD primarily based on studies in mice (Hoe et al., 2006; Kocherhans et al., 2010; Pujadas et al., 2014; Rice et al., 2013; Rossi et al., 2020) and functional genomic analysis in humans (Gao et al., 2015), but genome-wide association in humans has been lacking. This evidence concerns the gene RELN and Alzheimer disease.