In particular, by affecting the Eg5 localization and the microtubule organization (Fig. 5, A to E), the XPD/R683W mutation has deleterious consequences for mitosis, resulting in misaligned chromosomes, lagging chromosomes, and chromatin bridges (Fig. 4, C and D), which likely lead to cytokinesis defects (fig. The gene discussed is KIF11; the disease is xeroderma pigmentosum group D.