SPOCD1 encodes a TFIIS-family transcription factor and has been reported to promote the progression and metastasis of several types of cancer, including bladder and ovarian cancers, and osteosarcoma and glioblastoma, by activating signaling pathways such as the EGFR and VEGFR pathways [127–130]. This evidence concerns the gene SPOCD1 and osteosarcoma.