Another research confirmed by HP-13C-pyruvate metabolism in in vivo renal tumor tissue that, compared with benign renal tumors, approximately 70–80% of renal cell carcinomas (RCC) had increased lactate production and extracellular translocation was increased, and its aberrant metabolism was mainly caused by increased expression of LDHA and MCT4 [34]. Here, LDHA is linked to hereditary clear cell renal cell carcinoma.