The changes in renal redox capacity and mitochondrial PDH activity on day 7 after injury in unilateral rat kidneys were observed by HP-[1-13C]-dehydroascorbate and13C-pyruvate MRSI, respectively, and it was found that on day 7 of ischemia–reperfusion injury, renal 13C-vitamin C-to-vitamin C plus dehydroascorbate ratio and 13C-bicarbonate-to-13C-pyruvate ratio were reduced, consistent with their low redox capacity, and PDH activity was impaired [43]. This evidence concerns the gene PDP1 and ischemia.