Guiding in discerning a tauopathy (PSP and/or CBD) from a Ctrl frontal cortex was the proposed astrocytic tauopathy signature depicted in Fig. 6b, with increased accessibilities for TF binding sites related to the IER such as JUN, FOS, and its ligands FOSL1 and FOSL2. The gene discussed is FOSL2; the disease is tauopathy.