In contrast, when investigating the expression of Cathepsin D, a lysosomal hydrolase and marker of lysosomal degradation [48], we found an inverse association with CTSD + TAs (in PSP), while the fraction of CTSD + APs (in CBD) was not significantly higher than their GFAP + counterparts (PSP 0.44 vs. 0.84, ncells = (65; 18), ncases = 3; CBD 0.91 vs. 0.85, ncells = (87; 36), ncases = 4) (Fig. 7b). Here, CTSD is linked to supranuclear palsy, progressive, 1.