Stroke incidence was 0.58%/year in patients without diabetes, 0.64%/year in diabetic patients not receiving insulin (HR 1.11, 95% CI 0.72–1.71, p = 0.64 vs no diabetes) and 1.80%/years in diabetic patients receiving insulin (HR 3.11, 95% CI 1.91–5.07, p < 0.0001 vs no diabetes). This evidence concerns the gene INS and stroke disorder.