Insulin-requiring diabetes had a higher risk of MI (1.04%/years) vs both no diabetes (HR 2.58, 95% CI 1.37–4.86, p = 0.003) and non-insulin-requiring diabetes (HR 2.40, 95% CI 1.12–5.12, p = 0.024) (Table 2). The gene discussed is INS; the disease is diabetes mellitus.