Overall mortality was 3.36%/year in patients without diabetes, 5.02%/year in those with diabetes without insulin therapy (HR 1.50, 95% CI 1.27–1.75, p < 0.0001 vs no diabetes) and 8.91%/year in insulin-treated patients (HR 2.66, 95% CI 2.14–3.30, p < 0.0001 vs no diabetes) (Fig. 4). This evidence concerns the gene INS and diabetes mellitus.