INS and diabetes mellitus: Rates of intracranial hemorrhage were 0.18%/year in non-diabetic patients, 0.18%/year in diabetic patients without insulin therapy (HR 0.97, 95% CI 0.43–2.17, p = 0.93 vs no diabetes) and 0.56%/year in diabetic patients on insulin (HR 3.04, 95% CI 1.28–7.22, p = 0.012 vs no diabetes) (Table 2).