AD is pathologically defined by the presence of senile plaques (extracellular deposit of Aβ) and neurofibrillary tangles (intraneuronal accumulation of hyperphosphorylated tau protein), in addition to signs of a neurodegenerative process (neuronal and synaptic loss, astrogliosis and microglial activation)12,.19 Here, MAPT is linked to Alzheimer disease.