They are widely used inthe treatment and prevention of mycoses due to their broad-spectrum activity andbecause they inhibit the cytochrome P-450-dependent enzyme lanosterol14α-demethylase (CYP51) encoded by the ERG11 gene that convertslanosterol to ergosterol in the cell membrane, inhibiting fungal growth andreplication (31). This evidence concerns the gene CYP51A1 and fungal infectious disease.