Besides, PADN could inhibited the messenger ribonucleic acidexpression of genes correlated with inflammation, proliferation, andvasoconstriction[26].Huang et al.[27] also proved thatserum interleukins (IL)-1β, IL-6, and malondialdehyde levels in the PADNgroup were significantly lower than those in the sham operation group, and theactivity of superoxide dismutase was significantly increased, suggesting that PADNmay inhibit lung tissue inflammation and that oxidative stress reduces PAH. Here, IL6 is linked to pulmonary arterial hypertension.