To evaluate potential tumor suppressor function(s) of Atrx or Daxx in murine β cells, we crossed conditional alleles to the RIP-CreTg line and established a cohort of Atrxfl/flRIP-CreTg or Atrxfl/Y RIP-CreTg, as Atrx is on the X chromosome (abbreviated AR), and Daxxfl/flRIP-CreTg (DR) mice compared with both RIP-CreTg (R) and Cre negative [wild-type (WT)] controls (Fig. 1A). Here, DAXX is linked to neoplasm.