Because we observed high levels of basal IFN-λ2 secretion in TOs, which were resistant to HCMV infection, and high induction of IFN-λ2 in DOs infected with HCMV, we next determined whether inhibiting this IFN signaling would alter the sensitivity of DOs or TOs to HCMV infection. This evidence concerns the gene IFNA1 and cytomegalovirus infection.