CXCL8 and cytomegalovirus infection: We found that TOs secreted relatively few cytokines in response to HCMV infection, including pentraxin-3 (PTX3), first described as an endothelial factor induced by IL-1β treatment (Breviario et al., 1992), IL-8, and IL-11 (Figure 8A, C and D, Figure 8—figure supplement 2A).