AKT1 and neuroblastoma: ERK inhibition by an MEK inhibitor activates the mTORC2–AKT signaling axis downstream of epidermal growth factor (EGF; Yu et al., 2002), and a similar increase in AKT activation by ERK inhibition was reported in anaplastic lymphoma kinase-addicted neuroblastoma (Umapathy et al., 2017).