SERPINB1 and mental disorder: Several studies have reported E-I imbalances in the mPFC of mouse models of mental disorders and in patients affected by these diseases (Trakoshis et al., 2020; Sohal and Rubenstein, 2019; Medendorp et al., 2021; Ferguson and Gao, 2018; Hamm et al., 2017; Zick et al., 2018).