ANPEP and infection: By contrast, endemic human CoVs, including 229E, have been shown to actively enter and replicate in blood‐derived monocytic cells and macrophages (Desforges et al, 2007; Funk et al, 2012), in line with the detectable expression of the cellular 229E‐specific receptor CD13/APN (Yeager et al, 1992; Funk et al, 2012) and triggering a strong infection‐induced type I interferon responses in the monocytic cell compartments (Cheung et al, 2005; Desforges et al, 2007).