By contrast, the high IFN induction of the low pathogenic HCoV 229E early upon infection, is thought to be beneficial for a rapid, immune‐mediated viral clearance, whereas the highly pathogenic HCoVs SARS‐CoV and SARS‐CoV‐2 encode numerous viral antagonists to evade innate signaling, eventually resulting in blunted activation of the host cellular immunity and delayed viral clearance in vivo (Fung & Liu, 2019; Kim & Shin, 2021). Here, IFNA1 is linked to infection.