Then abundant ABL could directly interact with APAF1, a new identified RNA‐binding protein (RBP), to inhibit the intrinsic apoptosis pathway by competitively blocking the interaction of APAF1 with Cyt c, thus blocking apoptosome assembly and caspase‐9/3 activation, which led to resistance to cell death in GC cells. Here, APAF1 is linked to gastric cancer.