Frequently targeted genes for mutation in MSI tumors include BRAF (which is mutated in >8% of all CRC cases), ACVR2A, TGFBR2, MSH3, and MSH6 along with Wnt pathway regulators RNF43, RNF213, and ZNRF3 [20, 21]. Here, ZNRF3 is linked to colorectal carcinoma.