Moreover, members of several gene families appeared in the top 10 lists, such as KRAS, NRAS and HRAS in the SNA-based oncogenic events list, histones HIST2H2BE and HIST1H3B in the CNA-based oncogenic events list, or lysine methyltransferases KMT2C and KMT2D in the SNA-based tumour suppressor events list. The gene discussed is KMT2C; the disease is neoplasm.