CSMD1, SYNE1, RYR1, RYR3, APC, ADGRV1M, DCHS2, KRAS, LRP1B, and FAT4 were significantly downregulated (Figure 3(a)) Furthermore, the relationship between the expression of somatically mutated genes and progression-free survival (PFS) in CRC was investigated. The gene discussed is RYR3; the disease is colorectal carcinoma.