At present, PD-1/PD-L1 inhibitors are relatively commonly used in the immunotherapy of colorectal cancer, and their efficacy is relatively favorable in patients with deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) types, and the efficacy in patients with other subtypes needs to be further explored, in which the level of PD-L1 expression may have an impact on the efficacy [8]. This evidence concerns the gene CD274 and colorectal cancer.