AVP and Hyponatremia: It has been postulated that a low serum sodium level may lead to an upregulation of ACE-2 receptors, thereby inviting a more significant load of viral particles culminating in increased disease severity.3 Hyponatremia is one of the most common electrolyte abnormalities in patients with SARS-CoV-2 infection.4,5 Hyponatremia has been linked to an increase in the release of antidiuretic hormone (ADH) from hypothalamo-hypophyseal axis stimulation due to illness and stress, pneumonia-induced lung injury, direct/indirect renal injury, or a cytokine storm.