One interest of the present work is the identification of several components of the Ub system known to be overexpressed in cancers that correspond to developmental genes highly expressed in the embryonic cerebral cortex under physiological conditions but are not related to tumour formation or progression, for instance Ube2c (E2 gene), Trim28, Trim32, and Trim59 (E3 genes). The gene discussed is TRIM59; the disease is cancer.