Although the results of our study also showed that recombinant netrin-1 notably reduced B-ALL cell apoptosis by binding with Unc5b, the apoptosis rate of UNC5B interfering cells, however, did not decrease compared with that of vector control cells, which suggested that Unc5b did not function as a typical dependent receptor in B-ALL cells. Here, UNC5B is linked to precursor B-cell acute lymphoblastic leukemia.