NTN1 and precursor B-cell acute lymphoblastic leukemia: Finding a key regulator which induces the Bcl-2 upregulation and anti-apoptosis effects in B-ALL could make sense to expand the potential application of Bcl-2 related regimens for relapsed or refractory B-ALL.Netrin-1 (encoded by the NTN1 gene), belongs to a family of secreted laminin-related proteins, and has been proven to play an essential role in axon guidance during the development of the nervous system [9–11].