MAPT and frontotemporal dementia: The association between synaptic deficits and Aβ pathology was reported in transgenic (Tg) mouse models overexpressing Aβ [25–27] while the association between synaptic deficits and tau pathology was outlined in Tg models overexpressing tau protein (with or without frontotemporal dementia mutations) [6, 12, 21, 27].